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KMID : 0043320150380061232
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Archives of Pharmacal Research
2015 Volume.38 No. 6 p.1232 ~ p.1237
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Effects of CYP2C9*1/*3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects
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Lee Yun-Jeong
Byeon Ji-Yeong
Kim Young-Hoon
Kim Se-Hyung
Bae Jung-Woo
Choi Chang-Ik
Bae Jung-Woo
Sohn Uy-Dong
Jang Choon-Gon
Lee Jeong-Mi
Lee Seok-Yong
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Abstract
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The aim of this study was to investigate the impact of CYP2C9*1/*3 genotype on the pharmacokinetics of flurbiprofen and its metabolite. The CYP2C9 genotypes were determined with the use of polymerase chain reaction and restriction fragment and DNA sequencing analysis in 358 healthy Koreans. Among them, twenty individuals with CYP2C9*1/*1 (n = 12) or CYP2C9*1/*3 (n = 8) genotypes received a single 40 mg oral dose of flurbiprofen. The plasma concentrations of flurbiprofen and its metabolite, 4′-hydroxyflurbiprofen were measured by HPLC. AUCinf of flurbiprofen was significantly higher and its clearance was significantly lower in the CYP2C9*1/*3 individuals than in those with CYP2C9*1/*1. The AUC ratio of 4'-hydroxyflurbiprofen to flurbiprofen was significantly lower in the CYP2C9*1/*3 individuals than in those with CYP2C9*1/*1. These results indicate that the individuals carrying of CYP2C9*3 have significant reduction in flurbiprofen metabolism. The clinical use of this information may allow for more efficient personalized pharmacotherapy.
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KEYWORD
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CYP2C9, Flurbiprofen, Genotype, Allele, Polymorphisms
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